ACS Applied Materials & Interfaces 2016, 8
Efficient Inhibition of Protein Aggregation, Disintegration of Aggregates, and Lowering of Cytotoxicity by Green Tea Polyphenol-Based Self-Assembled Polymer Nanoparticles. Koushik Debnath, Shashi Shekhar, Vipendra Kumar, Nihar R.Covalent Functionalization of Organic Nanoparticles Using Aryl Diazonium Chemistry and Their Solvent-Dependent Self-Assembly. ACS Sustainable Chemistry & Engineering 2017, 5 Hyperbranched Polyglycerol Grafting on the Surface of Silica-Coated Nanoparticles for High Colloidal Stability and Low Nonspecific Interaction. Prasanta Panja, Pradip Das, Kuheli Mandal, and Nikhil R.ACS Applied Materials & Interfaces 2017, 9 Vitamin C-Conjugated Nanoparticle Protects Cells from Oxidative Stress at Low Doses but Induces Oxidative Stress and Cell Death at High Doses. The Role of Colloidal Stability and Charge in Functionalization of Aqueous Quantum Dots. ACS Biomaterials Science & Engineering 2019, 5 Designed Polymer Micelle for Clearing Amyloid Protein Aggregates via Up-Regulated Autophagy. ACS Applied Materials & Interfaces 2019, 11 Use of Core-Cross-Linked Polymeric Micelles Induced by the Selective Detection of Cu(II) Ions for the Sustained Release of a Model Drug. Biomedical Applications of Functional Polyaspartamide-Based Materials. This article is cited by 15 publications. This developed approach can be used to derive biocompatible nanobioconjugates for various biomedical applications.
The present approach has advantages over existing approaches as coating and functionalization can be performed in one pot and functional nanoparticles have <12 nm hydrodynamic size, high colloidal stability, and biocompartibility. This approach has been extended to different hydrophobic nanoparticles and biomolecules. The aspartimide group is then reacted with primary amine containing chemical/biomolecule with the formation of water-soluble functional nanoparticle. We have designed amphiphilic polyaspartimide that can anchor hydrophobic nanoparticle through octadecyl groups, leaving the polar polyethylene glycol and aspartimide groups exposed outwards. Here we report amphiphilic poly(amino acid)-based one-pot coating and conjugation approach that can transform hydrophobic nanoparticle into water-soluble nanoparticle functionalized with primary amine, thiol, and biomolecule. However, most of the high quality nanoparticles are hydrophobic in nature due to surfactant capping and their conversion into water-soluble functional nanoparticle via appropriate coating and conjugation chemistry is extremely critical issue. Functionalization of nanoparticles with chemical and biochemical is essential for their biomedical and other application.